SARS-CoV-2 inochengeterwa mumuviri wevarwere inogona kunge iri chikonzero cheiyo covid refu

Masayendisiti anga achitsvaga genetic zvinhu kubva kuhutachiona hwecovid-19 mumasampuli ezvituru kubva kuvarwere vane hutachiona kubva pakatanga denda: yaimbove ingori tsanangudzo, kuda kuziva, iko zvino humbowo hwave kutanga kubuda hwekuti chiitiko ichi chine hukama necovid refu. uye inogona kunge ichiratidzira homwe dzinoramba dziripo dzehutachiona mumuviri wevarwere.

Kunyanya, vaongorori vanoratidza kuvepo kweSARS-CoV-2 mapuroteni muropa re65% yevarwere vane covid yenguva refu, kunyanya hutachiona spike, mukati memwedzi gumi nemiviri yekutanga kuongororwa. Hafu yehupenyu hwemapuroteni akadaro mumuviri ipfupi, saka kuvapo kwavo kunoramba kuri humbowo hweimwe mhando yenzvimbo inoshanda yehutachiona pane imwe nzvimbo mumuviri.

Spike mapuroteni uye coronavirus RNA akawanikwa muvarwere vecovid kwenguva refu, zvichida zvichikonzera zviratidzo zvinoramba zviripo (Mufananidzo: Vladimirzotov / Envato Elements)
Spike mapuroteni uye coronavirus RNA akawanikwa muvarwere vecovid kwenguva refu, zvichida zvichikonzera zviratidzo zvinoramba zviripo (Mufananidzo: Vladimirzotov / Envato Elements)

Stealth virus uye refu covid.

Zvidzidzo pamusoro penyaya iyi zvakatanga mushure meongororo yakaona covid virus RNA muzvituru samples kubva kuvarwere vane vana multi-system inflammatory syndrome, isingawanzo asi yakakomba mamiriro ayo anogona kurova mavhiki mana mushure mekutapukirwa neSARS-CoV-2, uye inewo spike protein. uye mareki eropa anobuda muura sezviratidzo.

Kurapwa nemushonga wakadzikisira kupera kwematumbo kwakakonzera kukurumidza kucheneswa kweprotein yespike kubva kumasampuli uye kuvandudzwa kwezviratidzo, zvichitungamira kune fungidziro yekuti zvimwe chete zvinogona kuitika nevarwere venguva refu yecovid. protein haina kuonekwa.

Vamwe vanachiremba vakaona kushingirira kwehutachiona, sekudaidzwa kwazvinoitwa nenyanzvi, muvanhu vakapora kubva kuCovid: Vanosvika gumi nenhatu muzana vavo vakanga vachiri kudurura RNA mumasampuli ezvituru mwedzi mina mushure mekutapukirwa, uye 13% vaienderera mberi mushure memwedzi minomwe. Varwere ava vakashuma zviratidzo zvemudumbu zvakaita sekusvotwa, kurutsa, uye kurwadziwa nemudumbu, zvakare vakafunga zviratidzo zvenguva refu zvecovid. Izvi zvinogona kuva mhinduro yekudzivirira muviri nekuda kwekuvapo kwehutachiona mumatumbo.

Iko kushandiswa kweantivirals kunogona kuitwa kana pesvedzero yemavhairasi reserves mumuviri mune refu covid yakasimbiswa, asi zvimwe zvidzidzo zvinodikanwa (Mufananidzo: Twenty20photos/Envato Elements)
Iko kushandiswa kweantivirals kunogona kuitwa kana pesvedzero yemavhairasi reserves mumuviri mune refu covid yakasimbiswa, asi zvimwe zvidzidzo zvinodikanwa (Mufananidzo: Twenty20photos/Envato Elements)

Chidzidzo chekutarisa matishu emudumbu kubva kuvanhu makumi mana nevatanhatu vane chirwere chekuzvimba bowel vakapora kubva kunyoro covid vakawana hutachiona RNA kana protein mu46% yavo mwedzi minomwe mushure mekutapukirwa. Vanenge zvikamu zviviri muzvitatu vavo vakashuma zviratidzo zvinoramba zvichiitika, zvakadai sekuneta uye matambudziko ekuyeuka, nepo pasina dambudziko iri rakabata vanhu vasina zvidimbu zvehutachiona zvakaonekwa.

Imwe tsvakiridzo yekutanga yakawana mavhairasi, mune dzimwe nguva, achiri kudzokorora mune dzimwe nzvimbo dzemuviri, semeso, uropi nemoyo, mwedzi yakawanda mushure mekutapukirwa. Kushingirira uku kunoonekwa mune zvimwe zvirwere, zvakaita seEbola, iyo inohwanda munzvimbo dzisingasvikike masoja emumuviri, zvakaita semachende nemabhonzo, uye zvinoitawo kuti vapedzisire vave nezviratidzo zvinoramba zvichiitika.

Ikozvino, masayendisiti ari kutsvaga kuongorora kunyange akakura masampula evarwere, uye nekuwedzera tsvakiridzo kuitira kuti zvikwanise kugadzira mishonga inoshanda, senge antivirals, kurwisa covid kwenguva refu. Nyanzvi, zvisinei, dzinoti kushandiswa kwemhando iyi yemushonga kwakaoma, sezvo ichigona kufarira kuchinjika kwehutachiona: marapirwo maviri kana katatu anorongwa, nekuongororwa kwakawanda, sezvo isingadiwi, chero nzira, kubvumira a supermutation. tiza utachiona kubva kuvarwere.

Kunobva: medRxiv, NCBI

Tommy Banks
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